Random

When I was small, I realized a very important facet of my station as a fully-dependent human child: I was not the master of my own fate. My eating, sleeping, bathing times and locations were entirely regulated, along with the clothes I wore, the foods I ate, and the people with whom I was allowed to visit. I was basically a tiny prisoner in some posh minimum-security facility, like a diminutive swanky corporate tax evader or miniature ponzi schemer.

Nobody told me this: I just figured it out. After all, the evidence was overwhelming. For instance, I had no desire to clad my lower half in rust-brown Toughskins pants with knees so reinforced they made me look like an elementary-school robot made of corduroy.

And turtlenecks. Fucking turtlenecks. Every kid wearing a turtleneck looks like they’re being Raleigh St. Clair for Halloween, and no kid is ever being Raleigh St. Clair for Halloween, and do you know why? Because no kid has ever heard of Raleigh St. Clair. Additionally, for the whole day, it feels like maybe you are coming down with a sore throat — a sort of gentle squeezing all day long (or, as the brilliant and departed comedian Mitch Hedberg said, “like you’re being choked by a really weak guy”). I did not choose and would not have chosen that ensemble. I wanted to wear flouncy dresses and sparkly cowboy boots. Sadly, my father had determined that dressing like a Barbie would make my brain stop growing, so really, the Toughskins were for my own protection. (more…)

I had just crossed lazily through the intersection toward Wells Fargo Center, gently swinging my bag in the late afternoon heat. I had also decided that day to make friends with the hips I had developed over the past six months and lean into them … literally.

I saw him, 30-ish, scruffy, with a dirty T-shirt and a backward hat, leaning against the building. Our city has its contingent of panhandlers. They add a little paprika to our lives and I didn’t pay him any mind — until he called out to me as I passed by him.

“What?!” I asked, incredulously while laughing, stopped in my tracks.

‘I asked if you were married,” he answered with a crooked smile.

“Yes,” I replied and started to walk away. He wasn’t done, though. “Can I get your number and text you?” he yelled at me.

I turned around. “HAPPILY married!” I shot back and spun around on my heel and walked off, laughing. (more…)

I remember her waiting up for my father
To come home from God knows where
In a yellow cab at 2:00 A.M.
And waiting for me in the school parking lot
In our old blue station wagon
When whatever it was I was practicing for
Ran late …

And I remember her waiting for me
At the airport when I got back from Japan,
Waiting for everything to be all right,
Waiting for her biopsy results.
Waiting.
— George Bilgere, “Waiting”
 

Waiting for Cancer

In 1956, in On the Origin of Cancer Cells, Otto Warburg tried to pin down the causes for the “mysterious latency period of the production of cancer.” Fifty years later, in Genetic Progression and the Waiting Time to Cancer, Niko Beerenwinkel, Tibor Antal, David Dingli, Arne Traulsen, Kenneth W Kinzler, Victor E Velculescu, Bert Vogelstein, and Martin A Nowak replace the “mysterious latency period” with talk about a waiting period: they set out to “derive an analytical formula for the expected waiting time for the progression from benign to malignant tumor.” They started with a “normal” cell and predicted the number of mutations the cell will undergo. Based on the number of mutations, they could calculate how long it will take for a normal cell to produce a benign tumor and how long before those mutations produce a tumor that becomes malignant. (more…)